GGGG Motifs Intron 3 Splicing by DQB 1 Promotion of Position - Dependent Repression

GGGG Motifs Intron 3 Splicing by DQB 1 Promotion of Position - Dependent Repression and

Position - Dependent Repression and Promotion of DQB 1 Intron

Ddh334 3189..3202

We show that the allele-dependent expression of transcripts encoding soluble HLA-DQb chains is determined by branchpoint sequence (BPS) haplotypes in DQB1 intron 3. BPS RNAs associated with low inclusion of the transmembrane exon in mature transcripts showed impaired binding to splicing factor 1 (SF1), indicating that alternative splicing of DQB1 is controlled by differential BPS recognition ea...

Mechanisms of activation and repression by the alternative splicing factors RBFOX1/2.

RBFOX1 and RBFOX2 are alternative splicing factors that are predominantly expressed in the brain and skeletal muscle. They specifically bind the RNA element UGCAUG, and regulate alternative splicing positively or negatively in a position-dependent manner. The molecular basis for the position dependence of these and other splicing factors on alternative splicing of their targets is not known. We...

Splicing repression allows the gradual emergence of new Alu-exons in primate evolution

Alu elements are retrotransposons that frequently form new exons during primate evolution. Here, we assess the interplay of splicing repression by hnRNPC and nonsense-mediated mRNA decay (NMD) in the quality control and evolution of new Alu-exons. We identify 3100 new Alu-exons and show that NMD more efficiently recognises transcripts with Alu-exons compared to other exons with premature termin...